Dr. Anna Pfalzer is a Research Assistant Professor in the Department of Neurology at Vanderbilt University Medical Center. Her research focuses on identifying early molecular biomarkers of pathology in neurodegenerative diseases, specifically Huntington Disease (HD). To this end, she is currently working to develop a research program that examines the intersection between neurodevelopment and neurodegeneration in Huntington’s Disease with the primary goal to develop effective disease modifying therapies. Her work utilizes in vivo and in vitro models of HD as well as clinical research studies to generate a proteomic profile of the earliest molecular changes in HD and to design experiments using our basic research models to investigate the potential for novel proteins identified in our proteomic screen to modify mutant Huntingtin pathology and disease manifestation. Within COMBINEDBrain, she uses her expertise in basic research models of neurological diseases to identify and validate novel biochemical markers of neurodevelopmental outcome measures.
Dr. Pfalzer joined the Koolen-de Vries Syndrome Foundation as their Chief Scientific Officer in January 2023.