Dr. Michael Overholtzer

Professor and Dean

Cell Biology Program

Gerstner Sloan Kettering Graduate School of Biomedical Sciences

Memorial Sloan Kettering Cancer Center

Contact Information

Memorial Sloan Kettering Cancer Center

1275 York Avenue

New York, NY 10065

Email: [email protected]

Telephone Number: 212-639-6536

Education

Postdoctoral Fellow: Harvard Medical School, 2002-2008

PhD: Princeton University, 1996-2002

BA: Ithaca College, 1992-1996

Research Interests

The Overholtzer laboratory studies mechanisms that regulate autophagy, lysosomes, and cell death. Dr. Overholtzer also serves as the Dean of the Gerstner Sloan Kettering Graduate School of Biomedical Sciences at the Memorial Sloan Kettering Cancer Center. Research from the lab focuses on mechanisms of cell death that impact normal development and cancer, and mechanisms that control lysosome trafficking and turnover in health and disease.

Selected Publications

1. Klein AD, Petruzzi KL, Lee, C, Overholtzer M. (2024) Stress-induced microautophagy is coordinated with biogenesis and regulated by PIKfyve. Mol Biol Cell. May 1;35(5). PMID: 38536415.

2. Bandyopadhyay U, Todorova P, Pavlova NN, Tada Y, Thompson CB, Finley LWS, Overholtzer M. (2022) Leucine retention in lysosomes is regulated by starvation. Proc Natl Acad Sci U.S.A. Feb 8;119(6). PMID: 35105808.

3. Lee C, Lamech L, Johns E, Overholtzer M. (2020) Selective lysosome membrane turnover is induced by nutrient starvation. Dev Cell. Nov 9;55(3):289-297. PMID: 32916093.

4. Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon SJ, Wiesner U, Bradbury MS, Niethammer P, Zaritsky A, Overholtzer M. (2020) Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat Cell Biol. Sep; 22(9):1042-1048. PMID: 32868903.

5. Kim SE, Zhang L, Ma K, Riegman M, Chen F,Ingold I, Conrad M, Gao M, Jiang X, Monette S, Mohan P, Chen F, GonenM, Zanzonico P, Quinn T, Wiesner U, Bradbury MS, Overholtzer M.(2016) Ultrasmall Nanoparticles Induce Ferroptosis of Nutrient-Deprived Cancer Cells and Suppress Tumor Growth. Nat Nanotechnol. Nov;11(11):977-985. PMID: 27668796.